Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway
M Tian, P Ma, Y Zhang, Y Mi, D Fan - International Immunopharmacology, 2020 - Elsevier
Ginsenosides have a variety of pharmacological activities, including immunomodulatory,
antitumor and anti-inflammatory activities. However, the effect of Rk3 on ulcerative colitis has
rarely been reported. This study evaluated the effect of Rk3 on DSS-induced ulcerative
colitis and preliminarily explored the anti-inflammatory mechanisms. Rk3 administration
significantly attenuated the weight loss, increased DAI scores, colonic shortening, and
increased MPO and iNOS activities caused by DSS in mice. Histological improvement was …
antitumor and anti-inflammatory activities. However, the effect of Rk3 on ulcerative colitis has
rarely been reported. This study evaluated the effect of Rk3 on DSS-induced ulcerative
colitis and preliminarily explored the anti-inflammatory mechanisms. Rk3 administration
significantly attenuated the weight loss, increased DAI scores, colonic shortening, and
increased MPO and iNOS activities caused by DSS in mice. Histological improvement was …
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